3TR

Identification of the molecular mechanisms of non-response to treatments, relapses and remission in autoimmune, inflammatory, and allergic conditions

Summary

Many patients with autoimmune, inflammatory and allergic diseases do not respond well or at all to current treatments. A major challenge for researchers is to understand which patients are most likely to respond to which treatments. The aim of 3TR is to shed new light on the factors that determine whether or not a patient is likely to respond to a given treatment. 3TR will focus on seven diseases: systemic lupus erythematosus (SLE), rheumatoid arthritis, multiple sclerosis, ulcerative colitis, Crohn’s disease, asthma, and chronic obstructive pulmonary disease (COPD). Despite their diverse symptoms, these diseases have some molecular patterns in common, suggesting that patients with different diseases may share some markers that predict the likelihood of treatment response and disease progression.

The project will analyse data and samples from 50 000 patients who took part in 50 clinical trials. They will also carry out a new clinical study that will take samples (of diseased tissue, blood, stool and other fluids) from patients before, during and after treatment. The project will add all of its data to a centralised data management platform that will make it easier to analyse using state-of-the-art methods. The samples collected and the knowledge base will be maintained beyond the end of the project to allow further research. The project will ultimately make it easier to provide the right treatment to the right patient, thereby increasing the proportion of patients taking a treatment that works for them.

Participants

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EFPIA companies
  • Astrazeneca AB, Södertälje, Sweden
  • F. Hoffmann-La Roche AG, Basel, Switzerland
  • Glaxosmithkline Research And Development LTD., Brentford, Middlesex, United Kingdom
  • Janssen Pharmaceutica Nv, Beerse, Belgium
  • Novartis Pharma AG, Basel, Switzerland
  • Pfizer Limited, Sandwich, Kent , United Kingdom
  • Sanofi-Aventis Deutschland GMBH, Frankfurt / Main, Germany
  • Takeda Pharmaceuticals International AG, Glattpark-Opfikon (Zurich), Switzerland
Universities, research organisations, public bodies, non-profit groups
  • Academisch Medisch Centrum Bij De Universiteit Van Amsterdam, Amsterdam, Netherlands
  • Academisch Ziekenhuis Groningen, Groningen, Netherlands
  • Agencia Estatal Consejo Superior De Investigaciones Cientificas, Madrid, Spain
  • Azienda Ospedale Universita Padova, Padova, Italy
  • Azienda Ospedaliero-Universitaria Anna Meyer, Firenze, Italy
  • Centre Hospitalier Regional Universitaire Nancy, Nancy Cedex, France
  • Charite - Universitaetsmedizin Berlin, Berlin, Germany
  • Christian-Albrechts-Universitaet Zu Kiel, Kiel, Germany
  • Clinique Universitaire Saint-Luc Asbl, Brussels, Belgium
  • Consorci Institut D'Investigacions Biomediques August Pi I Sunyer, Barcelona, Spain
  • Consorcio Centro De Investigacion Biomedica En Red M.P., Madrid, Spain
  • Deutsches Rheuma-Forschungszentrum Berlin, Berlin, Germany
  • European Lung Foundation, Sheffield, United Kingdom
  • European Respiratory Society, Lausanne, Switzerland
  • Fondazione Irccs Ca' Granda - Ospedale Maggiore Policlinico, Milan, Italy
  • Fundacio Centre De Regulacio Genomica, Barcelona, Spain
  • Fundacion Publica Andaluza Progreso Y Salud, Seville , Spain
  • Imperial College Of Science Technology And Medicine, London, United Kingdom
  • Institut National De La Sante Et De La Recherche Medicale, Paris, France
  • Instituto De Medicina Molecular Joao Lobo Antunes, Lisboa, Portugal
  • Karolinska Institutet, Stockholm, Sweden
  • Katholieke Universiteit Leuven, Leuven, Belgium
  • Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften Ev, Munich, Germany
  • Medizinische Hochschule Hannover, Hannover, Germany
  • Orebro University, Örebro, Sweden
  • Philipps Universitaet Marburg, Marburg, Germany
  • Queen Mary University Of London, London, United Kingdom
  • Region Hovedstaden, Hilleroed, Denmark
  • Servicio Andaluz De Salud, Sevilla, Spain
  • Servicio Madrileno De Salud, Madrid, Spain
  • Stichting Vumc, Amsterdam, Netherlands
  • Technische Universitaet Dresden, Dresden, Germany
  • The Queen'S University Of Belfast, Belfast, United Kingdom
  • The University Of Manchester, Manchester, United Kingdom
  • Universita Degli Studi Del Piemonte Orientale Amedeo Avogadro, Vercelli, Italy
  • Universita Degli Studi Di Cagliari, Cagliari, Italy
  • Universita Degli Studi Di Catania, Catania, Italy
  • Universita Degli Studi Di Genova, Genova, Italy
  • Universita Di Pisa, Pisa, Italy
  • Universitat Basel, Basel, Switzerland
  • Universite De Bretagne Occidentale, Brest, France
  • Universiteit Gent, Gent, Belgium
  • Universiteit Hasselt, Hasselt, Belgium
  • Universitetet I Bergen, P.O. Box 7800, Bergen, Norway
  • University College Dublin, National University Of Ireland, Dublin, Dublin, Ireland
  • University College London, London, United Kingdom
  • University Of Glasgow, Glasgow, United Kingdom
  • University Of Leicester, Leicester, United Kingdom
  • University Of Southampton, Southampton, United Kingdom
  • University of Cambridge, Cambridge, United Kingdom
  • Universytet Medyczny W Lodzi., Lodz, Poland
  • Vib Vzw, Zwijnaarde - Gent, Belgium
Small and medium-sized enterprises (SMEs) and mid-sized companies (<€500 m turnover)
  • Alacris Theranostics GMBH, Berlin, Germany
  • Atrys Health, SA, Madrid, Spain
  • Eurice European Research And Project Office GMBH, Saarbrücken, Germany
  • Genos Doo Za Vjestacenje I Analizu, Osijek, Croatia
  • Lupus Europe, Brussels, Belgium
  • Owlstone Medical Limited, Cambridge, United Kingdom
  • Sip Service S.R.L., Milano, Italy
  • Societe De Pneumologie De Langue Francaise, Paris 6, France
Patient organisations
  • European Federation Of Asthma &Allergy Associations Ideell Forening, Brussels, Belgium
Third parties
  • Agencia Publica Empresarial Sanitaria Hospital De Poniente, El Ejido Almeria, Spain
  • Centre Hospitalier Regional Et Universitaire De Brest, Brest, France
  • Fundacion Para La Investigacion Biomedica De Cordoba, Cordoba, Spain
  • Fundacion Para La Investigacion Biomedica Del Hospital Universitario Clinico San Carlos, Madrid, Spain
  • Fundacion Para La Investigacion Biosanitaria De Andalucia Oriental-Alejandro Otero, Granada, Spain
  • Fundacion Publica Andaluza Para La Investigacion De Malaga En Biomedicina Y Salud, Malaga, Spain
  • Greater Glasgow Health Board, Glasgow, United Kingdom
  • Hospital Clinic De Barcelona, Barcelona, Spain
  • Orebro Lans Landsting, Orebro, Sweden
  • Region Stockholm, Stockholm, Sweden
  • Universitatsspital Basel, Basel, Switzerland
  • Universite Paris-Saclay, Saint Aubin, France
  • University Hospitals Of Leicester Nhs Trust, Leicester, United Kingdom

Participants
NameIHI funding in €
Academisch Medisch Centrum Bij De Universiteit Van Amsterdam717 221
Academisch Ziekenhuis Groningen120 875
Agencia Estatal Consejo Superior De Investigaciones Cientificas287 500
Alacris Theranostics GMBH106 250
Atrys Health, SA237 563
Azienda Ospedale Universita Padova277 004
Azienda Ospedaliero-Universitaria Anna Meyer146 350
Centre Hospitalier Regional Universitaire Nancy825 031
Charite - Universitaetsmedizin Berlin541 266
Christian-Albrechts-Universitaet Zu Kiel2 700 000
Clinique Universitaire Saint-Luc Asbl439 093
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer1 263 392
Consorcio Centro De Investigacion Biomedica En Red M.P.201 513
Deutsches Rheuma-Forschungszentrum Berlin229 595
Eurice European Research And Project Office GMBH1 917 499
European Federation Of Asthma &Allergy Associations Ideell Forening70 416
European Lung Foundation110 675
European Respiratory Society361 390
Fondazione Irccs Ca' Granda - Ospedale Maggiore Policlinico815 450
Fundacio Centre De Regulacio Genomica1 665 250
Fundacion Publica Andaluza Progreso Y Salud9 806 530
Genos Doo Za Vjestacenje I Analizu106 502
Imperial College Of Science Technology And Medicine241 799
Institut National De La Sante Et De La Recherche Medicale125 000
Instituto De Medicina Molecular Joao Lobo Antunes290 996
Karolinska Institutet537 974
Katholieke Universiteit Leuven890 500
Lupus Europe78 750
Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften Ev565 628
Medizinische Hochschule Hannover285 965
Orebro University542 947
Owlstone Medical Limited139 500
Philipps Universitaet Marburg201 565
Queen Mary University Of London2 320 291
Region Hovedstaden201 780
Servicio Andaluz De Salud724 750
Servicio Madrileno De Salud193 725
Sip Service S.R.L.201 500
Societe De Pneumologie De Langue Francaise196 425
Stichting Vumc836 689
Technische Universitaet Dresden192 500
The Queen'S University Of Belfast161 202
The University Of Manchester682 941
Universita Degli Studi Del Piemonte Orientale Amedeo Avogadro294 945
Universita Degli Studi Di Cagliari294 925
Universita Degli Studi Di Catania145 303
Universita Degli Studi Di Genova236 249
Universita Di Pisa292 500
Universitat Basel5 000
Universite De Bretagne Occidentale290 500
Universiteit Gent57 358
Universiteit Hasselt247 825
Universitetet I Bergen209 618
University College Dublin, National University Of Ireland, Dublin343 955
University College London560 011
University of Cambridge1 170 878
University Of Glasgow137 358
University Of Leicester490 148
University Of Southampton201 498
Universytet Medyczny W Lodzi.80 600
Vib Vzw361 019
 
Third parties
NameFunding in €
Agencia Publica Empresarial Sanitaria Hospital De Poniente52 250
Centre Hospitalier Regional Et Universitaire De Brest37 500
Fundacion Para La Investigacion Biomedica De Cordoba387 688
Fundacion Para La Investigacion Biomedica Del Hospital Universitario Clinico San Carlos193 725
Fundacion Para La Investigacion Biosanitaria De Andalucia Oriental-Alejandro Otero241 375
Fundacion Publica Andaluza Para La Investigacion De Malaga En Biomedicina Y Salud23 063
Greater Glasgow Health Board63 643
Hospital Clinic De Barcelona310 451
Orebro Lans Landsting420 175
Region Stockholm46 525
Universitatsspital Basel484 569
University Hospitals Of Leicester Nhs Trust33 750
 
Total Cost40 273 196