Summary
Many patients with autoimmune, inflammatory and allergic diseases do not respond well or at all to current treatments. A major challenge for researchers is to understand which patients are most likely to respond to which treatments. The aim of 3TR is to shed new light on the factors that determine whether or not a patient is likely to respond to a given treatment. 3TR will focus on seven diseases: systemic lupus erythematosus (SLE), rheumatoid arthritis, multiple sclerosis, ulcerative colitis, Crohn’s disease, asthma, and chronic obstructive pulmonary disease (COPD). Despite their diverse symptoms, these diseases have some molecular patterns in common, suggesting that patients with different diseases may share some markers that predict the likelihood of treatment response and disease progression.
The project will analyse data and samples from 50 000 patients who took part in 50 clinical trials. They will also carry out a new clinical study that will take samples (of diseased tissue, blood, stool and other fluids) from patients before, during and after treatment. The project will add all of its data to a centralised data management platform that will make it easier to analyse using state-of-the-art methods. The samples collected and the knowledge base will be maintained beyond the end of the project to allow further research. The project will ultimately make it easier to provide the right treatment to the right patient, thereby increasing the proportion of patients taking a treatment that works for them.
Achievements & News
May 2024
The 3TR project successfully identified gene expression pathways that could distinguish between people whose lupus was active versus people whose...
June 2023
The standards were developed by a multi-stakeholder group including people living with asthma as well as doctors, pharmaceutical companies, and...
Participants
Show participants on mapEFPIA companies
- Astrazeneca AB, Södertälje, Sweden
- Bristol-Myers Squibb Company Corp, Princeton, NJ, United States
- F. Hoffmann-La Roche AG, Basel, Switzerland
- Glaxosmithkline Research And Development LTD., Brentford, Middlesex, United Kingdom
- Janssen Pharmaceutica Nv, Beerse, Belgium
- Novartis Pharma AG, Basel, Switzerland
- Pfizer Limited, Sandwich, Kent , United Kingdom
- Sanofi-Aventis Deutschland GMBH, Frankfurt / Main, Germany
- Takeda Pharmaceuticals International AG, Glattpark-Opfikon (Zurich), Switzerland
Universities, research organisations, public bodies, non-profit groups
- Academisch Ziekenhuis Groningen, Groningen, Netherlands
- Agencia Estatal Consejo Superior De Investigaciones Cientificas, Madrid, Spain
- Azienda Ospedale Universita Padova, Padova, Italy
- Azienda Ospedaliera Universitaria Meyer Irccs, Firenze, Italy
- Centre Hospitalier Regional Universitaire Nancy, Nancy Cedex, France
- Charite - Universitaetsmedizin Berlin, Berlin, Germany
- Christian-Albrechts-Universitaet Zu Kiel, Kiel, Germany
- Cliniques Universitaires Saint-Luc Asbl, Brussels, Belgium
- Consorcio Centro De Investigacion Biomedica En Red M.P., Madrid, Spain
- Consorcio Para La Explotacion Del Centro Nacional De Analisis Genomico, Barcelona, Spain
- Deutsches Rheuma Forschungszentrumberlin, Berlin, Germany
- European Lung Foundation, Sheffield, United Kingdom
- European Respiratory Society, Lausanne, Switzerland
- Fondazione Irccs Ca' Granda - Ospedale Maggiore Policlinico, Milan, Italy
- Fundacio De Recerca Clinic Barcelona-Institut D Investigacions Biomediques August Pi I Sunyer, Barcelona, Spain
- Fundacion Publica Andaluza Progreso Y Salud M.P., Seville , Spain
- Imperial College Of Science Technology And Medicine, London, United Kingdom
- Institut National De La Sante Et De La Recherche Medicale, Paris, France
- Instituto De Medicina Molecular Joao Lobo Antunes, Lisboa, Portugal
- Karolinska Institutet, Stockholm, Sweden
- Katholieke Universiteit Leuven, Leuven, Belgium
- Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften Ev, Munich, Germany
- Medizinische Hochschule Hannover, Hannover, Germany
- Orebro University, Örebro, Sweden
- Philipps Universitaet Marburg, Marburg, Germany
- Queen Mary University Of London, London, United Kingdom
- Region Hovedstaden, Hilleroed, Denmark
- Servicio Andaluz De Salud, Sevilla, Spain
- Servicio Madrileno De Salud, Madrid, Spain
- Stichting Amsterdam Umc, Amsterdam, Netherlands
- Technische Universitaet Dresden, Dresden, Germany
- The Queen'S University Of Belfast, Belfast, United Kingdom
- The University Of Manchester, Manchester, United Kingdom
- Universita Degli Studi Del Piemonte Orientale Amedeo Avogadro, Vercelli, Italy
- Universita Degli Studi Di Cagliari, Cagliari, Italy
- Universita Degli Studi Di Catania, Catania, Italy
- Universita Degli Studi Di Genova, Genova, Italy
- Universita Di Pisa, Pisa, Italy
- Universitat Basel, Basel, Switzerland
- Universite De Bretagne Occidentale, Brest, France
- Universiteit Gent, Gent, Belgium
- Universiteit Hasselt, Hasselt, Belgium
- Universitetet I Bergen, P.O. Box 7800, Bergen, Norway
- University College Dublin, National University Of Ireland, Dublin, Dublin, Ireland
- University College London, London, United Kingdom
- University Of Glasgow, Glasgow, United Kingdom
- University Of Leicester, Leicester, United Kingdom
- University Of Southampton, Southampton, United Kingdom
- University of Cambridge, Cambridge, United Kingdom
- Universytet Medyczny W Lodzi., Lodz, Poland
- Vib Vzw, Zwijnaarde - Gent, Belgium
Small and medium-sized enterprises (SMEs) and mid-sized companies (<€500 m turnover)
- Alacris Theranostics GMBH, Berlin, Germany
- Atrys Health, SA, Madrid, Spain
- Eurice European Research And Project Office GMBH, Saarbrücken, Germany
- Genos Doo Za Vjestacenje I Analizu, Osijek, Croatia
- Lupus Europe, Brussels, Belgium
- Owlstone Medical Limited, Cambridge, United Kingdom
- Societe De Pneumologie De Langue Francaise, Paris 6, France
Patient organisations
- European Federation Of Asthma &Allergy Associations Ideell Forening, Brussels, Belgium
Third parties
- Centre Hospitalier Regional Et Universitaire De Brest, Brest, France
- Fundacion Para La Investigacion Biomedica De Cordoba, Cordoba, Spain
- Fundacion Para La Investigacion Biomedica Del Hospital Universitario Clinico San Carlos, Madrid, Spain
- Fundacion Para La Investigacion Biosanitaria De Andalucia Oriental-Alejandro Otero, Granada, Spain
- Fundacion Para La Investigacion De Malaga En Biomedicina Y Salud, Malaga, Spain
- Greater Glasgow Health Board, Glasgow, United Kingdom
- Helse Bergen Hf, Bergen, Norway
- Hospital Clinic De Barcelona, Barcelona, Spain
- Orebro Lans Landsting, Orebro, Sweden
- Region Stockholm, Stockholm, Sweden
- Universitatsspital Basel, Basel, Switzerland
- Universite Paris-Saclay, Saint Aubin, France
- University Hospitals Of Leicester Nhs Trust, Leicester, United Kingdom
Participants | |
---|---|
Name | EU funding in € |
Academisch Medisch Centrum Bij De Universiteit Van Amsterdam (left the project) | 758 721 |
Academisch Ziekenhuis Groningen | 120 875 |
Agencia Estatal Consejo Superior De Investigaciones Cientificas | 412 500 |
Alacris Theranostics GMBH | 106 250 |
Atrys Health, SA | 237 563 |
Azienda Ospedale Universita Padova | 277 004 |
Azienda Ospedaliera Universitaria Meyer Irccs | 201 500 |
Centre Hospitalier Regional Universitaire Nancy | 825 031 |
Charite - Universitaetsmedizin Berlin | 541 266 |
Christian-Albrechts-Universitaet Zu Kiel | 2 700 000 |
Cliniques Universitaires Saint-Luc Asbl | 434 093 |
Consorcio Centro De Investigacion Biomedica En Red M.P. | 201 513 |
Consorcio Para La Explotacion Del Centro Nacional De Analisis Genomico | 906 456 |
Deutsches Rheuma Forschungszentrumberlin | 229 595 |
Eurice European Research And Project Office GMBH | 1 917 499 |
European Federation Of Asthma &Allergy Associations Ideell Forening | 70 416 |
European Lung Foundation | 110 675 |
European Respiratory Society | 361 390 |
Fondazione Irccs Ca' Granda - Ospedale Maggiore Policlinico | 1 016 200 |
Fundacio Centre De Regulacio Genomica (left the project) | 758 794 |
Fundacio De Recerca Clinic Barcelona-Institut D Investigacions Biomediques August Pi I Sunyer | 1 258 392 |
Fundacion Publica Andaluza Progreso Y Salud M.P. | 9 468 780 |
Genos Doo Za Vjestacenje I Analizu | 106 502 |
Imperial College Of Science Technology And Medicine | 241 799 |
Institut National De La Sante Et De La Recherche Medicale | 125 000 |
Instituto De Medicina Molecular Joao Lobo Antunes | 285 996 |
Karolinska Institutet | 537 974 |
Katholieke Universiteit Leuven | 890 500 |
Lupus Europe | 78 750 |
Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften Ev | 565 628 |
Medizinische Hochschule Hannover | 285 965 |
Orebro University | 542 947 |
Owlstone Medical Limited | 139 500 |
Philipps Universitaet Marburg | 201 565 |
Queen Mary University Of London | 2 471 391 |
Region Hovedstaden | 201 780 |
Servicio Andaluz De Salud | 756 250 |
Servicio Madrileno De Salud | 193 725 |
Sip Service S.R.L. (left the project) | 750 |
Societe De Pneumologie De Langue Francaise | 196 425 |
Stichting Amsterdam Umc | 1 595 410 |
Technische Universitaet Dresden | 192 500 |
The Queen'S University Of Belfast | 161 202 |
The University Of Manchester | 677 941 |
Universita Degli Studi Del Piemonte Orientale Amedeo Avogadro | 289 945 |
Universita Degli Studi Di Cagliari | 289 925 |
Universita Degli Studi Di Catania | 145 303 |
Universita Degli Studi Di Genova | 236 249 |
Universita Di Pisa | 292 500 |
Universitat Basel | 5 000 |
Universite De Bretagne Occidentale | 290 500 |
Universiteit Gent | 57 358 |
Universiteit Hasselt | 247 825 |
Universitetet I Bergen | 109 241 |
University College Dublin, National University Of Ireland, Dublin | 343 955 |
University College London | 560 011 |
University of Cambridge | 1 170 878 |
University Of Glasgow | 137 358 |
University Of Leicester | 490 148 |
University Of Southampton | 201 498 |
Universytet Medyczny W Lodzi. | 80 600 |
Vib Vzw | 361 019 |
Third parties | |
Name | Funding in € |
Centre Hospitalier Regional Et Universitaire De Brest | 37 500 |
Fundacion Para La Investigacion Biomedica De Cordoba | 382 688 |
Fundacion Para La Investigacion Biomedica Del Hospital Universitario Clinico San Carlos | 193 725 |
Fundacion Para La Investigacion Biosanitaria De Andalucia Oriental-Alejandro Otero | 262 125 |
Fundacion Para La Investigacion De Malaga En Biomedicina Y Salud | 23 063 |
Greater Glasgow Health Board | 63 643 |
Helse Bergen Hf | 100 376 |
Hospital Clinic De Barcelona | 310 451 |
Orebro Lans Landsting | 420 175 |
Region Stockholm | 46 525 |
Universitatsspital Basel | 484 569 |
University Hospitals Of Leicester Nhs Trust | 33 750 |
Total Cost | 41 031 916 |