CARDIATEAM

Cardiomyopathy in type 2 diabetes mellitus

Summary

Diabetic patients are 2.5 times more likely to develop heart failure than people without diabetes. In many patients, the diabetes causes a type of heart dysfunction called cardiomyopathy, which is characterised by functional and structural abnormalities in the heart. Currently, the underlying causes of diabetic cardiomyopathy remain unknown, and there are no effective treatments.

The CARDIATEAM project aims to determine how distinct diabetic cardiomyopathy is from other forms of heart failure, and the extent to which type 2 diabetes contributes to its development and progression. The team will recruit 1 600 people with a range of cardiometabolic disorders, including people with diabetes, and follow them for 3 years. By studying this group in detail over time, the team hopes to be able to deliver biological markers that would indicate which diabetes patients are at greatest risk of developing diabetic cardiomyopathy, as well as a more detailed understanding of the disease.

Ultimately, the project results will make it easier to provide people with diabetes with more personalised approaches to managing their condition and preventing diabetic cardiomyopathy.

Participants

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EFPIA companies
  • Bayer Aktiengesellschaft, Leverkusen, Germany
  • Eli Lilly And Company LTD, Basingstoke, United Kingdom
Universities, research organisations, public bodies, non-profit groups
  • Assistance Publique Hopitaux De Paris, Paris, France
  • Consorcio Centro De Investigacion Biomedica En Red M.P., Madrid, Spain
  • Helmholtz Zentrum Muenchen Deutsches Forschungszentrum Fuer Gesundheit Und Umwelt GMBH, Neuherberg, Germany
  • Hospices Civils De Lyon, lyon, France
  • Institut National De La Sante Et De La Recherche Medicale, Paris, France
  • Katholieke Universiteit Leuven, Leuven, Belgium
  • Luxembourg Institute Of Health, Luxembourg, Luxembourg
  • SIB Institut Suisse De Bioinformatique, CH-660-0733998-3, Genève, Switzerland
  • Stichting Netherlands Heart Institute, Utrecht, Netherlands
  • The Queen'S University Of Belfast, Belfast, United Kingdom
  • Universita Degli Studi Di Torino, Turin, Italy
  • Universitaetsklinikum Aachen, Aachen, Germany
  • Universite D'Aix Marseille, Marseille, France
  • Universiteit Maastricht, Maastricht, Netherlands
  • University Of Dundee, Dundee, United Kingdom
Small and medium-sized enterprises (SMEs) and mid-sized companies (<€500 m turnover)
  • Inserm Transfert SA, Paris, France
  • Metabrain Research, Maison-Alfort, France
  • Opale, Paris, France
Patient organisations
  • Universitatsklinikum Heidelberg, Heidelberg, Germany
Third parties
  • Academisch Ziekenhuis Groningen, Groningen, Netherlands
  • Centre D'Etude Et De Recherche Multimodal Et Pluridisciplinaire En Imagerie Du Vivant Gie, Bron Cedex, France
  • Clinical Trial Center Maastricht, Maastricht, Netherlands
  • Consorci Institut D'Investigacions Biomediques August Pi I Sunyer, Barcelona, Spain
  • Fundacio Hospital Universitari Vall D'Hebron - Institut De Recerca, Barcelona, Spain
  • Fundacion Para La Investigacion Biomedica Del Hospital Gregorio Maranon, Madrid, Spain
  • Institut De Recerca De L'Hospital De La Santa Creu I Sant Pau Fundacion, Barcelona, Spain
  • Stichting Vumc, Amsterdam, Netherlands
  • Universitair Medisch Centrum Utrecht, Utrecht, Netherlands

Participants
NameIHI funding in €
Assistance Publique Hopitaux De Paris387 500
Consorcio Centro De Investigacion Biomedica En Red M.P.365 113
Helmholtz Zentrum Muenchen Deutsches Forschungszentrum Fuer Gesundheit Und Umwelt GMBH269 526
Hospices Civils De Lyon137 084
Inserm Transfert SA310 250
Institut National De La Sante Et De La Recherche Medicale1 053 229
Katholieke Universiteit Leuven94 783
Luxembourg Institute Of Health588 156
Metabrain Research28 150
Opale392 481
SIB Institut Suisse De Bioinformatique, CH-660-0733998-3648 000
Stichting Netherlands Heart Institute21 875
The Queen'S University Of Belfast30 000
Universita Degli Studi Di Torino407 616
Universitaetsklinikum Aachen138 750
Universitatsklinikum Heidelberg124 975
Universite D'Aix Marseille213 375
Universiteit Maastricht140 625
University Of Dundee550 000
 
Third parties
NameFunding in €
Academisch Ziekenhuis Groningen107 812
Centre D'Etude Et De Recherche Multimodal Et Pluridisciplinaire En Imagerie Du Vivant Gie65 625
Clinical Trial Center Maastricht219 062
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer87 750
Fundacio Hospital Universitari Vall D'Hebron - Institut De Recerca50 879
Fundacion Para La Investigacion Biomedica Del Hospital Gregorio Maranon101 758
Institut De Recerca De L'Hospital De La Santa Creu I Sant Pau Fundacion50 000
Stichting Vumc57 813
Universitair Medisch Centrum Utrecht57 813
 
Total Cost6 700 000