imSAVAR

Immune safety avatar: nonclinical mimicking of the immune system effects of immunomodulatory therapies

Summary

Certain treatments for cancers and autoimmune diseases work by altering the immune system. However, a major challenge for researchers is identifying potential efficacy and safety issues with these treatments early in drug development, before they are tested in humans. Part of the problem is that the tests used early in drug development do not reflect the full complexity of the human immune system. In addition, these tests tend to be based on a healthy immune system, which is different to the immune system of someone who is ill.

The imSAVAR project aims to deliver a range of tools that will enhance our ability to assess the efficacy and safety of these immunomodulatory therapies. They also plan to develop new biological markers for diagnosing and predicting immune-mediated safety issues, and explore ways of mitigating them.

In the longer term, the project will help to deliver safer medicines for patients and also contribute to the ‘3Rs’ (i.e. the drive to replace, reduce and refine the use of animals in research).

Achievements & News

The secret life of tumours

In recent funding calls, IMI turned its attention to emerging cancer therapies, seeking better understanding of things like factors behind resistance to treatment and immunotherapy success. Two projects in this field were launched recently – IMMUCAN and imSAVAR.###

IMMUCAN aims to analyse the tumour tissue, blood, stool, saliva, and clinical data from about 3 000 patients to hopefully better understand the mechanisms of resistance to current treatments (including immunotherapy) that would enable identification of new therapeutic targets and identify biomarkers that can tell us who is most likely to respond well to what treatment.

imSAVAR is creating tools to help figure out the potential safety or efficacy issues of immune therapies in the early drug development stages. Currently, tests used early in drug development don’t reflect the full complexity of the human immune system, and they tend to be based on a healthy immune system. This means that it is hard to predict how safe or effective immune therapies are before they are tested in humans.

Read more

Participants

  Show participants on map
EFPIA companies
  • Boehringer Ingelheim Internationalgmbh, Ingelheim, Germany
  • F. Hoffmann-La Roche AG, Basel, Switzerland
  • Institut De Recherches Servier, Suresnes, France
  • Labcorp Early Development Laboratories Limited, Harrogate, United Kingdom
  • Merck Kommanditgesellschaft Auf Aktien, Darmstadt, Germany
  • Merck Sharp & Dohme Corp, Whitehouse Station, New Jersey, United States
  • Novartis Pharma AG, Basel, Switzerland
  • Sanofi-Aventis Recherche & Developpement, Chilly Mazarin, France
  • Transgene SA, Illkirch-Graffenstaden, France
Universities, research organisations, public bodies, non-profit groups
  • Academisch Ziekenhuis Leiden, Leiden, Netherlands
  • Bundesinstitut Fur Impfstoffe Und Biomedizinische Arzneimittel, Langen, Germany
  • Eberhard Karls Universitaet Tuebingen, Tuebingen, Germany
  • Fraunhofer Gesellschaft Zur Forderung Der Angewandten Forschung Ev, München, Germany
  • Lunds Universitet, Lund, Sweden
  • Medizinische Hochschule Hannover, Hannover, Germany
  • Medizinische Universitat Innsbruck, Innsbruck, Austria
  • Universitaet Leipzig, Leipzig, Germany
  • Universitaetsklinikum Wuerzburg - Klinikum Der Bayerischen Julius-Maximilians-Universitat, Wuerzburg, Germany
  • Universitatsklinikum Jena, Jena, Germany
  • Universite Du Luxembourg, Esch-sur-Alzette, Luxembourg
  • Universiteit Twente, Enschede, Netherlands
  • Universitetet I Oslo, Oslo, Norway
Small and medium-sized enterprises (SMEs) and mid-sized companies (<€500 m turnover)
  • Biosci Consulting Bvba, Maasmechelen, Belgium
  • Dynamic42 GMBH, Jena, Germany
  • Information Technology For Translational Medicine (Ittm) SA, Esch-sur-Alzette, Luxembourg
  • T-Curx GMBH, Wurzburg, Germany
Associated partners
  • Jdrf International, New York, United States

Participants
NameIHI funding in €
Academisch Ziekenhuis Leiden419 688
Biosci Consulting Bvba288 750
Bundesinstitut Fur Impfstoffe Und Biomedizinische Arzneimittel602 556
Dynamic42 GMBH88 750
Eberhard Karls Universitaet Tuebingen724 250
Fraunhofer Gesellschaft Zur Forderung Der Angewandten Forschung Ev3 720 804
Information Technology For Translational Medicine (Ittm) SA340 000
Lunds Universitet396 771
Medizinische Hochschule Hannover568 650
Medizinische Universitat Innsbruck366 485
T-Curx GMBH211 250
Universitaet Leipzig706 775
Universitaetsklinikum Wuerzburg - Klinikum Der Bayerischen Julius-Maximilians-Universitat978 100
Universitatsklinikum Jena519 475
Universite Du Luxembourg423 400
Universiteit Twente519 363
Universitetet I Oslo124 250
Total Cost10 999 317