PFAROS

Driving sustainable innovation to minimise PFAS in European healthcare

Summary

PFAS (per- and poly-fluoroalkyl substances) are synthetic chemicals which play a key role in ensuring the quality and safety of a wide range of healthcare products, from medicines and medical devices right through to packaging and cleaning agents. They are also hard to break down and so build up when released into the environment. Growing concerns about the impacts of PFAS on both human health and the environment mean there is now wide recognition of the need to limit their use.

The aim of PFAROS is to accelerate the move away from harmful PFAS substances in the pharmaceutical and medical technology sectors, while maintaining the quality and safety of products affected.

The PFAROS team will start by identifying how PFAS are used in the health sector today, and work to identify, develop and validate alternatives. The team will evaluate alternatives using a ‘safe and sustainable by design’ framework to ensure that they are both safe for patients and other users and environmentally sound throughout manufacture, use and disposal.

A core project output will be an AI-powered data tool, which will draw on data on PFAS use in health, alternatives to PFAS, toxicology data, chemical analyses and more. Once validated, the tool will support users when deciding how best to replace PFAS in different situations.

Looking to the future, and to guide decision-making, the project also plans to deliver a European roadmap to reduce PFAS emissions from healthcare. The team hopes that its tools and resources will help to pave the way for the elimination of PFAS in healthcare by 2050.

PFAROS will deliver impacts in a range of areas. Scientifically, it will drive innovations in the development of high quality, safe, environmentally-sound alternatives to PFAS. This in turn will trigger new business opportunities, position Europe as a leader in sustainable healthcare solutions, and boost the resilience of Europe’s life science sectors.

Most importantly, by replacing PFAS in healthcare the project will improve the safety of diverse healthcare products for patients, and contribute to a cleaner, healthier environment.

Participants

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EFPIA including Vaccines Europe
  • Abbvie Deutschland GMBH & Co Kg, Wiesbaden, Germany
  • Abbvie Inc, North Chicago Il, United States
  • Ares Trading SA, Coinsins, Switzerland
  • Astrazeneca Uk Limited, Cambridge, United Kingdom
  • Bayer Aktiengesellschaft, Leverkusen, Germany
  • Bayer Consumer Care AG, Basel, Switzerland
  • Bayer Healthcare Llc, Whippany, United States
  • Boehringer Ingelheim Corporate Center GmbH, Ingelheim am Rhein, Germany
  • Boehringer Ingelheim Internationalgmbh, Ingelheim, Germany
  • Boehringer Ingelheim Pharma GMBH &Co Kg, Ingelheim, Germany
  • Cilag GMBH International, Zug, Switzerland
  • Eli Lilly And Company, Indianapolis, United States
  • Eli Lilly And Company LTD, Basingstoke, United Kingdom
  • F. Hoffmann-La Roche AG, Basel, Switzerland
  • Gilead Sciences Inc, Foster City Ca, United States
  • Glaxosmithkline Research & Development Limited, London, United Kingdom
  • Institut De Recherches Internationales Servier, Gif-Sur-Yvette, France
  • Janssen Pharmaceutica Nv, Beerse, Belgium
  • Labcorp Early Development Laboratories Limited, Harrogate, United Kingdom
  • Lilly Deutschland GmbH, Bad Homburg, Germany
  • Merck Healthcare Kgaa, Darmstadt, Germany
  • Merck Kommanditgesellschaft Auf Aktien, Darmstadt, Germany
  • Merck Life Science Kgaa, Darmstadt, Germany
  • Merck S.L.U., Madrid, Spain
  • Merck Santé S.A.S., Lyon, France
  • Merck Serono S.A, Roma, Italy
  • Merck Serono SA, Geneve, Switzerland
  • Novartis Pharma AG, Basel, Switzerland
  • Novo Nordisk A/S, Bagsvaerd, Denmark
  • Oril Industrie, Bolbec, France
  • Pfizer Healthcare India Private Limited, TamilNadu, India
  • Pfizer Inc, New York City, United States
  • Pfizer Ireland Pharmaceuticals, Cork, Ireland
  • Pfizer Italia s.r.l., Latina, Italy
  • Pfizer R&D UK Limited, Sandwich, United Kingdom
  • Sanofi-Aventis Deutschland GMBH, Frankfurt Am Main, Germany
  • Sanofi-Aventis Recherche & Developpement, Gentilly, France
  • Sanofi Genzyme, Cambridge, United States
  • Sanofi R&D Vaccins, Lyon, France
  • Sanofi US Services Inc., Cambridge, Massachusetts, United States
  • Sanofi Winthrop Industrie, Gentilly, France
  • Technologie Servier, Orleans, France
  • UCB Biopharma, Bruxelles / Brussel, Belgium
  • UCB Pharma SA, Bruxelles / Brussel, Belgium
MedTech Europe
  • Biotronik Se & Co. Kg, Berlin, Germany
  • Edwards Lifesciences BV, Breda, Netherlands
  • Edwards Lifesciences Belgium BV, Dilbeek, Belgium
  • Edwards Lifesciences GMBH, Garching B. Munchen, Germany
  • Edwards Lifesciences Llc, Irvine California, United States
  • Edwards Lifesciences SARL, Nyon, Switzerland
  • Edwards Lifesciences SL, Valencia, Spain
  • Janssen Sciences Ireland UC, Cork, Ireland
  • Johnson & Johnson Services, Inc., New Brunswick, United States
  • Medical Device Business Services Inc, Warsaw, United States
  • Medical Devices & Diagnostics Global Services, LLC, Bridgewater, United States
  • Olympus Winter & Ibe GMBH, Hamburg, Germany
  • Roche Diagnostics International AG, Rotkreuz, Switzerland
  • Terumo Denmark, Filial Af Terumo Sweden AB, Herlev, DenmarkSME
  • Terumo Europe, Leuven, Belgium
  • Terumo France SAS, Rueil-Malmaison, FranceSME
  • Terumo Sweden AB, Västra Frölunda, SwedenSME
Universities, research organisations, public bodies, non-profit groups
  • Dvgw Deutscher Verein Des Gas- Undwasserfaches - Technisch-Wissenschaftlicher Verein Ev, Bonn, Germany
  • Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V., Munchen, Germany
  • Fundacio Institut Catala De Recerca De L'Aigua, Girona, Spain
  • Health Care Without Harm Europe, Bruxelles / Brussel, Belgium
  • Kobenhavns Universitet, Kobenhavn, Denmark
  • Luxembourg Institute Of Science And Technology, Esch Sur Alzette, Luxembourg
  • Norges Geotekniske Institutt As, Oslo, Norway
  • Rise Research Institutes Of Sweden AB, Boras, Sweden
  • Stichting Vu, Amsterdam, Netherlands
  • Stichting Wageningen Research, Wageningen, Netherlands
  • Stockholms Universitet, Stockholm, Sweden
  • Syddansk Universitet, Odense M, Denmark
  • The European Association Medical Devices-Notified Bodies, Sprimont, Belgium
  • Universitaetsklinikum Hamburg-Eppendorf, Hamburg, Germany
  • Universitat Wien, Wien, Austria
  • Universite Du Luxembourg, Esch-sur-Alzette, Luxembourg
  • Universiteit Antwerpen, Antwerpen, Belgium
  • Universiteit Gent, Gent, Belgium
  • Vlaamse Instelling Voor Technologisch Onderzoek N.V., Mol, Belgium
Small and medium-sized enterprises (SMEs) and mid-sized companies (<€500 m turnover)
  • Centre For Process Innovation Limited Lbg, Redcar Cleveland, United Kingdom
  • Co2 Dry BV, Weesp, Netherlands
  • Inopsys, Mechelen, Belgium
  • Mura Technology Limited, London, United Kingdom
  • Polysecure GMBH, Freiburg Im Breisgau, Germany
  • Richard Wolf GMBH, Knittlingen, Germany
COCIR
  • Ion Beam Applications SA, Ottignies Louvain La Neuve, Belgium
Other companies
  • ElringKlinger Kunststofftechnik GmbH, Bietigheim-Bissingen, Germany
  • Medicalmountains GMBH, Tuttlingen, Germany

Participants
NameEU funding in €
Centre For Process Innovation Limited Lbg523 760
Dvgw Deutscher Verein Des Gas- Undwasserfaches - Technisch-Wissenschaftlicher Verein Ev616 774
Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.4 085 528
Fundacio Institut Catala De Recerca De L'Aigua610 625
Health Care Without Harm Europe708 475
Kobenhavns Universitet449 995
Luxembourg Institute Of Science And Technology520 513
Medicalmountains GMBH350 530
Norges Geotekniske Institutt As755 810
Polysecure GMBH849 375
Rise Research Institutes Of Sweden AB3 001 122
Stichting Vu815 023
Stichting Wageningen Research750 238
Stockholms Universitet1 279 368
Syddansk Universitet749 375
The European Association Medical Devices-Notified Bodies180 313
Universitaetsklinikum Hamburg-Eppendorf188 975
Universitat Wien342 795
Universite Du Luxembourg678 080
Universiteit Antwerpen855 625
Universiteit Gent4 279 946
Vlaamse Instelling Voor Technologisch Onderzoek N.V.825 033
Total Cost23 417 278