European action for the diagnosis of early non-symptomatic type 1 diabetes for intervention


Some 9 million people worldwide have type 1 diabetes (T1D), in which the immune system attacks the cells in the pancreas that make the hormone insulin. Insulin controls our blood sugar levels, and people with T1D have to closely monitor their blood sugar levels and inject themselves with insulin to keep their condition under control.

Today, many people are only diagnosed when the disease has already caused significant damage to the insulin-producing cells. Research efforts to identify people with T1D earlier on in the disease have so far focused mainly on people with a family member with the disease. However, 90% of those diagnosed have no family history of T1D and so are not picked up by these efforts.

The aim of EDENT1FI is to change that by setting up a pan-European open platform to screen 200 000 children and adolescents for T1D. The project will assess the psychosocial, medical and economic impacts of screening for T1D in different health systems and populations. The team will also refine the biomarkers used to determine a person’s risk of developing T1D, how advanced the disease is, and how the disease should be monitored in different patients. Another part of the project will focus on designing clinical trials of novel treatments that could stop the disease in its tracks.

Ultimately, EDENT1FI hopes to pioneer a new approach to T1D diagnosis and care, with a much stronger focus on early detection and prevention of the disease. In the long term, learnings from the project could also be applied to other childhood diseases.


  Show participants on map
Universities, research organisations, public bodies, non-profit groups
  • Cardiff University, Cardiff, United Kingdom
  • European Diabetes Forum, Brussel, Belgium
  • Fakultni Nemocnice V Motole, Praha 5, Czechia
  • Hannoversche Kinderheilanstalt, Hannover, Germany
  • Helmholtz Zentrum Muenchen Deutsches Forschungszentrum Fuer Gesundheit Und Umwelt GMBH, Neuherberg, Germany
  • Katholieke Universiteit Leuven, Leuven, Belgium
  • King'S College London, London, United Kingdom
  • Medizinische Universitat Graz, Graz, Austria
  • Region Hovedstaden, Hilleroed, Denmark
  • Slaski Uniwersytet Medyczny W Katowicach, Katowice, Poland
  • Tampereen Korkeakoulusaatio Sr, Tampere, Finland
  • Technische Universitaet Dresden, Dresden, Germany
  • The University Of Birmingham, Birmingham, United Kingdom
  • Universita Degli Studi Di Siena, Siena, Italy
  • University of Oxford, Oxford, United Kingdom
  • University of Turku, Turku, Finland
  • Warszawski Uniwersytet Medyczny, Warsaw, Poland
Small and medium-sized enterprises (SMEs) and mid-sized companies (<€500 m turnover)
  • Critical Path Institute Stichting, Amsterdam, Netherlands
  • Digostics Limited, Didcot, United Kingdom
Patient organisations
  • Associacao Protectora Dos Diabeticos De Portugal, Lisboa, Portugal
Private companies
  • Diabetomics, Inc., Hillsboro, United States
  • Ospedale San Raffaele SRL, Milano, Italy
IHI industry partners
  • Imcyse SA, Sart Tilman, Belgium
  • Medtronic Bakken Research Center B.V., Maastricht, Netherlands
  • Medtronic International Trading SARL, Tolochenaz, Switzerland
  • Medtronic MiniMed, Inc., Northridge, United States
  • Novo Nordisk A/S, Bagsvaerd, Denmark
  • Provention Bio Inc, Red Bank, NJ, United States
  • Sanofi, Bridgewater, United States
  • Sanofi-Aventis Deutschland GMBH, Frankfurt / Main, Germany
  • Sanofi-Aventis Recherche & Developpement, Chilly Mazarin, France
Contributing partners
  • Jdrf International, New York, United States
  • The Leona M. And Harry B. Helmsley Charitable Trust, New York, United States

NameEU funding in €
Associacao Protectora Dos Diabeticos De Portugal286 250
European Diabetes Forum128 125
Fakultni Nemocnice V Motole413 125
Hannoversche Kinderheilanstalt236 250
Helmholtz Zentrum Muenchen Deutsches Forschungszentrum Fuer Gesundheit Und Umwelt GMBH3 482 504
Katholieke Universiteit Leuven2 754 583
Medizinische Universitat Graz96 875
Medtronic Bakken Research Center B.V.400 000
Ospedale San Raffaele SRL423 125
Region Hovedstaden354 375
Slaski Uniwersytet Medyczny W Katowicach407 656
Tampereen Korkeakoulusaatio Sr171 875
Technische Universitaet Dresden705 938
Universita Degli Studi Di Siena146 875
University of Turku146 875
Warszawski Uniwersytet Medyczny589 850
Total Cost10 744 281