Hypoglycaemia - REdefining SOLutions for better liVEs


Many diabetes patients experience hypoglycaemia, when their blood sugar levels become too low. Symptoms include behavioural changes, memory loss and confusion, which can result in accidents and falls and, in the worst cases, in hospitalisation or death. Worries about hypoglycaemia represent a serious psychological burden for people with diabetes.

Despite its seriousness, little is known about hypoglycaemia. The Hypo-RESOLVE project aims to change that by adding to our understanding of the underlying causes of the condition, as well as its predictors and consequences. They will also analyse the financial costs of hypoglycaemia. Ultimately, the hope is that the project results will pave the way for new, better treatments for people with diabetes that will help them to maintain healthy blood sugar levels.

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Constant threat of 'hypos' takes heavy toll on people with diabetes

The Hypo-RESOLVE project wants to single out the risk factors for severe hypoglycaemic episodes, where diabetes patients’ blood sugar levels fall to dangerously low levels. ###Although there are certain widely recognised risk factors for hypoglycaemia like exercise, skipped meals or insulin dosing errors, hypoglycaemic episodes very often also occur quite unexpectedly. If a ‘hypo’ occurs, you have to act quickly to bring your glucose levels back to normal and make sure you’re not a threat to yourself.

Needless to say, this often interferes directly with daily activities. Episodes can even occur without causing any symptoms, and sometimes recovery is spontaneous. Not uncommonly, a partner or family member recognises it before the patient does. ‘In the long term,’ says Hypo-RESOLVE coordinator Bastiaan de Galan of the Radboud University Medical Centre in Nijmegen, ‘hypo events can cause fear and avoidant behaviour, which makes overall glucose control even more difficult. Severe episodes can increase the risk of cardiovascular disease, although we don’t know yet whether this relation is causal.’

The Hypo-RESOLVE project wants to find out more about the mechanisms of hypoglycaemic episodes beyond what is already known, including their effect on the psychosocial well-being of people who experience them. In an interview with the IMI Programme office, Bastiaan de Galan and Jill Carlton of the University of Sheffield describe how the project is working to tackle the challenge of hypoglycaemic episodes.

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EFPIA companies
  • Abbott Diabetes Care, Alameda, United States
  • Eli Lilly And Company LTD, Basingstoke, United Kingdom
  • Medtronic International Trading SARL, Tolochenaz, Switzerland
  • Novo Nordisk A/S, Bagsvaerd, Denmark
Universities, research organisations, public bodies, non-profit groups
  • Centre Hospitalier Universitaire Montpellier, Montpellier, France
  • King'S College London, London, United Kingdom
  • Medizinische Universitat Graz, Graz, Austria
  • Region Hovedstaden, Hilleroed, Denmark
  • SIB Institut Suisse De Bioinformatique, CH-660-0733998-3, Genève, Switzerland
  • Stichting Radboud Universitair Medisch Centrum, Nijmegen, Netherlands
  • Syddansk Universitet, Odense, Denmark
  • The University Of Edinburgh, Edinburgh, United Kingdom
  • The University Of Sheffield, Sheffield, United Kingdom
  • Universita Degli Studi Di Padova, Padova, Italy
  • University Of Dundee, Dundee, United Kingdom
  • University Of Leicester, Leicester, United Kingdom
  • University of Cambridge, Cambridge, United Kingdom
Small and medium-sized enterprises (SMEs) and mid-sized companies (<€500 m turnover)
  • Eurice European Research And Project Office GMBH, Saarbrücken, Germany
Associated partners
  • Federation Internationale Du Diabete, Brussels, Belgium
  • Jdrf International, New York, United States
  • The Leona M. And Harry B. Helmsley Charitable Trust, New York, United States
  • Unitio Inc, Boston, United States
Third parties
  • Sheffield Teaching Hospitals Nhs Foundation Trust, Sheffield, United Kingdom
  • University Hospitals Of Leicester Nhs Trust, Leicester, United Kingdom

NameEU funding in €
Centre Hospitalier Universitaire Montpellier445 982
Eurice European Research And Project Office GMBH676 149
King'S College London385 703
Medizinische Universitat Graz828 737
Region Hovedstaden1 011 732
SIB Institut Suisse De Bioinformatique, CH-660-0733998-3934 250
Stichting Radboud Universitair Medisch Centrum2 008 957
Syddansk Universitet1 354 981
The University Of Edinburgh1 303 699
The University Of Sheffield2 000 222
Universita Degli Studi Di Padova392 688
Universite De Lausanne (left the project)955 601
University of Cambridge662 703
University Of Dundee383 623
University Of Leicester35 276
Third parties
NameFunding in €
Sheffield Teaching Hospitals Nhs Foundation Trust67 913
University Hospitals Of Leicester Nhs Trust1 841
Total Cost13 450 057