PD-MitoQUANT

PD-MitoQUANT – A quantitative approach towards the characterisation of mitochondrial dysfunction in Parkinson's disease

Summary

Mitochondria are the powerhouses of our cells. Mutations in the mitochondria appear to be associated with Parkinson’s disease, a neurodegenerative disease that affects around a million people in Europe. It is triggered by the death of neurons that produce a chemical called dopamine; in order to properly work, these neurons need a lot of energy.

Focusing on mitochondria dysfunction in Parkinson’s disease, the PD-MitoQUANT project aims to identify and validate molecular drivers and mechanisms of the condition and discover innovative therapeutic targets that can be further developed by the pharmaceutical companies. Current therapies can cause adverse side effects, and cannot stop, slow or reverse disease progression. This makes the improvement of Parkinson’s disease-related treatments even more urgently needed.

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Participants

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EFPIA companies
  • H. Lundbeck As, Valby, Denmark
  • Teva Pharmaceutical Industries Limited, Netanya, Israel
  • UCB Biopharma, Brussels, Belgium
Universities, research organisations, public bodies, non-profit groups
  • Centre National De La Recherche Scientifique Cnrs, Paris, France
  • Consiglio Nazionale Delle Ricerche, Roma, Italy
  • Deutsches Zentrum Fur Neurodegenerative Erkrankungen Ev, Bonn, Germany
  • Institut Du Cerveau Et De La Moelle Epiniere, Paris, France
  • Royal College Of Surgeons In Ireland, Dublin, Ireland
  • Stichting Radboud Universitair Medisch Centrum, Nijmegen, Netherlands
  • University College London, London, United Kingdom
Small and medium-sized enterprises (SMEs) and mid-sized companies (<€500 m turnover)
  • Genexplain GMBH, Wolfenbuttel, Germany
  • Mimetas BV, Leiden, Netherlands
  • Pintail LTD, Blackrock, Ireland
Associated partners
  • Parkinson'S Disease Society Of Theunited Kingdom Lbg, London, United Kingdom

Participants
NameIHI funding in €
Centre National De La Recherche Scientifique Cnrs158 463
Consiglio Nazionale Delle Ricerche541 146
Deutsches Zentrum Fur Neurodegenerative Erkrankungen Ev537 652
Genexplain GMBH147 921
Institut Du Cerveau Et De La Moelle Epiniere849 895
Mimetas BV249 228
Pintail LTD165 946
Royal College Of Surgeons In Ireland1 088 108
Stichting Radboud Universitair Medisch Centrum401 298
University College London358 278
Total Cost4 497 935