Summary
Prostate cancer is the second most common cancer in men, and accounts for 9 % of all cancer deaths in men. Currently, it is hard to predict which patients will respond best to different treatments, and which patients can be managed safely without undergoing treatment. The aim of PIONEER is to use big data to address key knowledge gaps related to the screening, diagnosis and treatment of prostate cancer patients. To do this, they will standardise and integrate existing ‘big data’ from sources such as clinical trials and electronic health records into a single, innovative data platform. The project will draw on this database to identify ways to improve prostate cancer outcomes and health system efficiency. The project will apply FAIR (‘findable, accessible, interoperable, and reusable’) principles to the data. Ultimately, the project results should feed back into clinical centres so that patients can benefit from the best possible care.
PIONEER is part of IMI’s Big Data for Better Outcomes (BD4BO) programme.
Achievements & News
The first two datasets have been added to the PIONEER big data platform, a major milestone for the IMI project. The researchers want to use real-world data from well-known prostate cancer studies to answer some vital questions about the disease. ###The first question they hope the data will help answer concerns the kind of variables that affect the prognosis for prostate cancer patients.
The two datasets will be followed by more; other partners are poised to add another 22 anonymised datasets to the platform, and PIONEER hopes that other data custodians, both private and public, will be encouraged to contribute. The ultimate aim is to improve the health and social care for all prostate cancer patients and their families.
Analytics will be run over the lifetime of the project to account for new and updated datasets. Both the OMOP/OHDSI platform for population-based registries and epidemiological research and the PIONEER omics analysis platform for cohort and clinical trial data were set up by The Hyve, a partner in the project.
Read more
- IMI’s news story
- Project website
- Project factsheet
- Follow @ProstatePioneer on Twitter
Participants
Show participants on mapEFPIA companies
- Astellas Pharma Europe BV, Leiden, Netherlands
- Astrazeneca AB, Södertälje, Sweden
- Bayer Aktiengesellschaft, Leverkusen, Germany
- Ims Information Solutions Medical Research Limited, London, United Kingdom
- Janssen Pharmaceutica Nv, Beerse, Belgium
- Labcorp Early Development Laboratories Limited, Harrogate, United Kingdom
- Nv SAS Institute SA, Tervuren, Belgium
- Orion Oyj, Espoo, Finland
- Sanofi-Aventis Recherche & Developpement, Chilly Mazarin, France
Universities, research organisations, public bodies, non-profit groups
- Association Eisbm, Vourles, France
- Erasmus Universitair Medisch Centrum Rotterdam, Rotterdam, Netherlands
- European Alliance for Personalised Medicine, Maribor, Slovenia
- European Organisation For Research And Treatment Of Cancer Aisbl, Brussels, Belgium
- Fraunhofer Gesellschaft Zur Forderung Der Angewandten Forschung Ev, München, Germany
- Goeteborgs Universitet, Gothenburg, Sweden
- Helmholtz-Zentrum Dresden-Rossendorf Ev, Dresden, Germany
- Imperial College Of Science Technology And Medicine, London, United Kingdom
- King'S College London, London, United Kingdom
- Lunds Universitet, Lund, Sweden
- Stichting Radboud Universiteit, Nijmegen, Netherlands
- Tampereen Korkeakoulusaatio Sr, Tampere, Finland
- Technische Universitaet Dresden, Dresden, Germany
- Universita Vita-Salute San Raffaele, Milano, Italy
- Universitaetsklinikum Hamburg-Eppendorf, Hamburg, Germany
- University Of Aberdeen, Aberdeen, United Kingdom
- Weizmann Institute Of Science, Rehovot, Israel
Small and medium-sized enterprises (SMEs) and mid-sized companies (<€500 m turnover)
- Ihe, Institutet For Halso- Och Sjukvardsekonomi Aktiebolag, Lund, Sweden
- International Consortium For Healthoutcomes Measurement LTD, London, United Kingdom
- Julius Clinical Research BV, Zeist, Netherlands
- Pinsent Masons Llp, London, United Kingdom
- Stichting European Urological Foundation, Arnhem, Netherlands
- The Ecancer Global Foundation, Bristol, United Kingdom
- The Hyve BV, Utrecht, Netherlands
- Ttopstart BV, Bilthoven, Netherlands
Patient organisations
- European Cancer Patient Coalition, Brussels, Belgium
| Participants | |
|---|---|
| Name | IHI funding in € |
| Association Eisbm | 700 000 |
| Cancer Intelligence Limited (left the project) | 12 121 |
| Erasmus Universitair Medisch Centrum Rotterdam | 415 349 |
| European Alliance for Personalised Medicine | 180 000 |
| European Cancer Patient Coalition | 79 994 |
| European Organisation For Research And Treatment Of Cancer Aisbl | 16 000 |
| Fraunhofer Gesellschaft Zur Forderung Der Angewandten Forschung Ev | 125 000 |
| Goeteborgs Universitet | 150 000 |
| Helmholtz-Zentrum Dresden-Rossendorf Ev | 62 500 |
| Ihe, Institutet For Halso- Och Sjukvardsekonomi Aktiebolag | 175 000 |
| Imperial College Of Science Technology And Medicine | 200 000 |
| International Consortium For Healthoutcomes Measurement LTD | 31 250 |
| King'S College London | 359 000 |
| Lunds Universitet | 185 761 |
| Pinsent Masons Llp | 150 000 |
| Stichting European Urological Foundation | 738 343 |
| Stichting Radboud Universiteit | 150 000 |
| Tampereen Korkeakoulusaatio Sr | 387 500 |
| Technische Universitaet Dresden | 125 000 |
| The Ecancer Global Foundation | 47 879 |
| The Hyve BV | 400 000 |
| Ttopstart BV | 237 500 |
| Universita Vita-Salute San Raffaele | 312 500 |
| Universitaetsklinikum Hamburg-Eppendorf | 150 000 |
| University Of Aberdeen | 409 303 |
| Weizmann Institute Of Science | 200 000 |
| Total Cost | 6 000 000 |
Alex Asiimwe
Bayer