REsolution

Add medical genetic solutions to RESOLUTE (REsolution)

Summary

Transport proteins act as our cells’ gate-keepers, controlling the flow of nutrients and other molecules (including drugs) into and out of the cell. The REsolution project focuses on solute carriers (SLCs); with over 400 members, SLCs are the largest group of transport proteins. Yet although they have been implicated in a number of diseases including Alzheimer’s disease, amyotrophic lateral sclerosis (ALS) and schizophrenia, SLCs have yet to be studied in detail.

The IMI project RESOLUTE is working hard to change that, and is delivering a wealth of open access tools, knowledge and resources on the biology and biochemistry of SLCs that will make it easier to identify SLCs that are involved in specific diseases. The aim of REsolution is to build on the work of RESOLUTE by adding genetics to the equation. Put simply, like all proteins, SLCs are created based on instructions encoded in our genes. Variations in these genes can result in variations in how the SLCs work, and this could explain why (for example) some people’s cells take up certain molecules more easily than others.

REsolution aims to gather existing data, and generate new knowledge on genetic variation in SLCs. Together with the information gathered by RESOLUTE, this will form a valuable resource that could help researchers to identify the SLCs (and their genetic variants) that are most clearly involved in diseases. This could in turn contribute to the development of new drugs to treat these diseases.

Participants

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EFPIA companies
  • Bayer Aktiengesellschaft, Leverkusen, Germany
  • Pfizer Limited, Sandwich, Kent , United Kingdom
Universities, research organisations, public bodies, non-profit groups
  • Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften Ev, Munich, Germany
  • The University Of Liverpool, Liverpool, United Kingdom
  • Universitat Wien, Vienna, Austria
  • Universiteit Leiden, Leiden, Netherlands
  • University of Oxford, Oxford, United Kingdom
Small and medium-sized enterprises (SMEs) and mid-sized companies (<€500 m turnover)
  • Axxam S.A, Bresso (Milan), Italy
  • Cemm - Forschungszentrum Fuer Molekulare Medizin GMBH, Vienna, Austria

Participants
NameIHI funding in €
Axxam S.A175 000
Cemm - Forschungszentrum Fuer Molekulare Medizin GMBH642 223
Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften Ev20 000
The University Of Liverpool20 000
Universitat Wien102 778
Universiteit Leiden20 000
University of Oxford20 000
Total Cost1 000 001