GRIP on MASH: global research initiative for patient screening on MASH


Some 30% of the world’s population has metabolic dysfunction-associated staetotic liver disease (MASLD), which is characterised by a build-up of fat in the liver. Many people with MASLD will have no symptoms, but some (around 1 in 5) will develop MASH (metabolic dysfunction-associated steatohepatitis). In MASH, the fat in the liver causes it to become inflamed and damaged. In the most serious cases, MASH can cause irreversible damage to the liver and can even lead to liver cancer. The scale of the problem is immense; MASH is expected to be the leading cause of liver transplants worldwide by 2030. Yet all too often, patients only find out that they have MASH when they develop serious complications such as cirrhosis or liver cancer.

The aim of the GRIPonMASH project is to design and set up a platform capable of diagnosing people who have MASLD, so that they can take steps to protect their liver and stop their condition from evolving into MASH.

The sustainable, scalable platform will allow the screening of people with known risk factors for MASLD (such as diabetes, metabolic syndrome, obesity, and high blood pressure). Decision-support tools based on artificial intelligence (AI) will draw on information from diverse blood tests to identify the people with MASLD who are at greatest risk of developing MASH.

Today, a diagnosis of MASH usually involves a liver biopsy, but GRIPonMASH plans to develop non-invasive alternatives based on imaging and organ-on-a-chip technologies, for example.

Finally, the platform will provide patients with personalised lifestyle advice to help them boost their liver function.

Ultimately, the project aims to get a ‘grip on MASH’ by transforming the way MASLD is detected and diagnosed.


  Show participants on map
Universities, research organisations, public bodies, non-profit groups
  • Academisch Ziekenhuis Leiden, Leiden, Netherlands
  • Associação para Investigação e Desenvolvimento da Faculdade de Medicina, Lisbon, Portugal
  • Charokopeio Panepistimio, Athens, Greece
  • Consiglio Nazionale Delle Ricerche, Roma, Italy
  • Fondation Cardiometabolisme Nutrition, Paris, France
  • Servicio Andaluz De Salud, Sevilla, Spain
  • Stichting Amsterdam Umc, Amsterdam, Netherlands
  • Universita Cattolica Del Sacro Cuore, Milan, Italy
  • Universitaetsmedizin Der Johannes Gutenberg-Universitaet Mainz, Mainz, Germany
  • Universitair Medisch Centrum Utrecht, Utrecht, Netherlands
  • Universitair Ziekenhuis Antwerpen, Edegem, Belgium
  • Universiteit Leiden, Leiden, Netherlands
  • Universiteit Maastricht, Maastricht, Netherlands
  • Université Libre de Bruxelles, Bruxelles, Belgium
  • Vseobecna Fakultni Nemocnice V Praze, Praha 2, Czechia
Small and medium-sized enterprises (SMEs) and mid-sized companies (<€500 m turnover)
  • Elevate BV, Utrecht, Netherlands
Patient organisations
  • European Atherosclerosis Society, Göteborg, Sweden
  • European Liver Patients Association, Bruxelles, Belgium
Third parties
  • Fondazione Policlinico Universitario Agostino Gemelli Irccs, Roma, Italy
  • Fundacion Publica Andaluza Para Lagestion De La Investigacion En Salud De Sevilla, Sevilla, Spain
Private companies
  • Exit071 BV, Leiden, Netherlands
  • Medical Education Research And Innovation Center S.R.L., Bucuresti Sectorul 1, Romania
IHI industry partners
  • Echosens, Paris, France
  • Mimetas BV, Leiden, Netherlands
  • Nordic Bioscience A/S, Herlev, Denmark
  • Novo Nordisk A/S, Bagsvaerd, Denmark
Contributing partners
  • Julius Clinical Research BV, Zeist, Netherlands
  • Mercodia Aktiebolag, Uppsala, Sweden
  • Metadeq Limited, London, United Kingdom

NameEU funding in €
Academisch Ziekenhuis Leiden10 000
Associação para Investigação e Desenvolvimento da Faculdade de Medicina640 000
Charokopeio Panepistimio740 000
Consiglio Nazionale Delle Ricerche500 029
Elevate BV631 391
European Atherosclerosis Society10 000
European Liver Patients Association30 000
Exit071 BV150 000
Fondation Cardiometabolisme Nutrition640 000
Julius Clinical Research BV2 930 644
Medical Education Research And Innovation Center S.R.L.678 125
Mimetas BV242 736
Servicio Andaluz De Salud407 264
Stichting Amsterdam Umc500 000
Universita Cattolica Del Sacro Cuore1 171 555
Universitaetsmedizin Der Johannes Gutenberg-Universitaet Mainz640 000
Universitair Medisch Centrum Utrecht929 092
Universitair Ziekenhuis Antwerpen580 400
Universiteit Leiden716 815
Universiteit Maastricht10 000
Université Libre de Bruxelles320 000
Vseobecna Fakultni Nemocnice V Praze673 476
Third parties
NameFunding in €
Fondazione Policlinico Universitario Agostino Gemelli Irccs151 375
Fundacion Publica Andaluza Para Lagestion De La Investigacion En Salud De Sevilla732 375
Total Cost14 035 277