IMI project ITCC-P4 addresses the urgent need for better tools to study childhood cancers
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Research by IMI project AMYPAD reveals that carrying out a PET scan of the brain could result in a faster, more certain diagnosis for patients.
Between them, IMI projects have produced almost 10 000 papers, and their quality matches their quantity, with many papers achieving high citation rates.
The app, developed by IMI project eTRANSAFE, makes it easier for researchers to analyse which biomarkers are being used in which clinical studies.
Results from the COMBACTE-CARE project show that – if approved – a new combination of drugs could help in the fight against some of the most dangerous drug-resistant bacteria.
By painting a detailed picture of the lung disease bronchiectasis in different European countries, the iABC project is helping to drive new research on the disease.
The standards were developed by a multi-stakeholder group including people living with asthma as well as doctors, pharmaceutical companies, and health policymakers.
EPND's Cohort Catalogue will help to accelerate the hunt for biological markers of neurodegenerative diseases like Alzheimer's and Parkinson's diseases.
Using smartphones to self-report and monitor thinking difficulties could help to monitor and manage depression, according to new research from IMI project RADAR-CNS.
Three IMI projects have contributed to UroEvidenceHub, a platform that will provide physicians with personalised healthcare recommendations for patients with urological conditions.
Data gathered during IMI project DIRECT helped scientists to pinpoint genetic variants associated with a good response to diabetes drugs called GLP-1 agonists.
IDEA-FAST’s research involved people with neurodegenerative and inflammatory diseases, where fatigue can have a major impact on patients’ quality of life.
iConsensus draws on the agility and specialist knowledge of SMEs and the know-how of academic experts to make biological drug development faster, cheaper and more efficient.
UNITE4TB explored how low- and middle-income countries can roll out the molecular diagnostic tests needed to determine the best course of treatment for people diagnosed with TB.
The IMI-PainCare project has developed a new electrode to investigate pain perception in a clinical recreation of chronic pain, a condition which affects 1 in 5 Europeans.
IMI project BIOMAP has uncovered previously unknown genetic factors associated with the onset of psoriasis, a disease that is characterised by red, scaly patches on the skin.
The project looked for compounds that stop the virus's spike protein from binding with the ACE2 receptor which is found on human cells and is the virus's main route of attack.
IMI project SOPHIA is shedding new light on the mechanisms that can cause type 2 diabetes in obesity, as well as the factors that keep some people with obesity diabetes-free.
IMI projects are presenting results on remote clinical trials, patient information, health data, and real world evidence at the upcoming event.
IMI psoriatic arthritis project HIPPOCRATES is a great example of best practice for patient involvement in research, and it’s already seeing the benefits of its approach.
LITMUS is studying how simple blood tests or scans could replace surgical biopsies as a means to identify people with the liver disease non-alcoholic staetohepatitis (NASH).
IMI project c4c has pioneered an advice process involving diverse experts including patients to aid drug developers when designing paediatric clinical trials.
IMI project TransBioLine is identifying new markers that flag up when a medicine may be harmful to vital organs such as the liver or kidneys, for example.
Many people with diabetes experience hypoglycaemia, when blood sugar levels become too low. IMI project Hypo-RESOLVE is shedding new light on the condition.
The guidance influenced the work of IMI project EPAD, which used biomarker tests to collect data on the early stages of Alzheimer's disease.
Research from IMI project PERISCOPE adds to picture of how infections and vaccines influence immune response.
Prostate cancer is the second most common cancer in men and its diagnosis - and treatment - can take a toll on emotional and mental health.
IMI projects EBiSC2 and FAIRplus are ensuring that EBiSC's data is FAIR, i.e. findable, accessible, interoperable and reusable; this should ultimately help to accelerate research.
The short brochure describes recent IMI project results in fields such as cancer, antimicrobial resistance, COVID-19 and more.
Laboratory studies show that a potential antibiotic dubbed NOSO-502 is active against some of the most dangerous drug-resistant bacteria. The next step will be to test it in humans...
The project hopes the CODE-EHR framework will boost confidence in the results of studies using real world data, and so trigger improvements in patient care.
INNODIA iVZW will secure the legacy of IMI diabetes projects INNODIA and INNODIA HARVEST, which have already delivered world class knowledge and resources on type 1 diabetes.
A study of scientific publications from IMI projects shows that collaborative papers, with diverse authorship, perform better than non-collaborative papers.
PharmaLedger's use cases are designed to build the case for the wider adoption of blockchain within the pharma industry.
Bigpicture has uploaded the first datasets to its platform, which aims to apply artificial intelligence to the field of pathology.
IMI project H2O has launched its first health outcomes observatories, in the Netherlands, Spain and now Austria.
IMI project HARMONY is proposing a new, more accurate way of assessing the prognosis of patients with multiple myeloma.
As Pierre Meulien completes his 7-year term as Executive Director of IHI, he reflects on how the research and innovation process has changed and will continue to undergo rapid...
IMI tuberculosis project TRIC-TB is using a novel approach to boost the efficacy of existing TB drugs.
Projects can often help each other reach their goals, as demonstrated by the IMI projects IMI-PainCare and EQIPD. Together, they are helping to bring better approaches for those...
Respiratory syncytial virus – also known as RSV – may not be a widely known disease, yet its impact is significant. It can lead to serious chest infections and causes over 100 000...
Taking patient preferences into consideration when developing a therapy would seem common sense. Yet it is only relatively recently that consultation has become formalised. IMI’s...
For the majority of people, vaccines have always been a part of our lives; we didn’t think about how they are developed or the diseases they control. However, the coronavirus...
Pregnancy should be a time of joy and excitement, although inevitably it is also one of apprehension and concern. Mothers want to be as sure as the can be that they are minimising...
Vaccine potency drops in the elderly and little is known about why this happens. Now European scientists are on a mission to understand waning immunity and to develop strategies...
Treating primary Sjögren’s syndrome poses a particular challenge; the wide range of symptoms has made it difficult to identify what works and what doesn’t. A potential breakthrough...
The COVID-19 lockdown has increased awareness of mental health issues – particularly clinical depression. However, clinical intervention relies on the individual presenting to...
The European Medicines Agency has issued a second Letter of Support to IMI project MACUSTAR for its work on new measures to assess the eye disease age-related macular degeneration...
COVID-19 vaccines do not raise the risk of developing four rare neurological disorders, but an increased risk was seen in unvaccinated infected people with the disease.
Scientists from IMI’s iPiE and PREMIER projects used ePiE to predict levels of ibuprofen in four major European river basins.
The IMI-funded CARE project helps speed up antibody drug discovery while opening a promising new avenue for antiviral research
IMI project EPAD has made genomic data from its study of the earliest stages of Alzheimer’s disease available to the wider research community.
While the incidence of Alzheimer’s disease continues to grow at an alarming rate, advances in treatment and prevention have stalled. IMI's ADAPTED project worked to better...
The IMI-funded European Lead Factory hopes to boost charity-funded science and ‘explore unchartered biological territory’
The IMI project IMPENTRI’s trial of a cancer drug has shown promising results after 90 days, confirming its benefits in severe cases.
IMI rare disease research focusses on gene therapy delivery systems, newborn screening, platform trials for neurofibromatosis and finding a cure for Fibrodysplasia ossificans...
IMI-funded IMSAVAR reviewed the state of ‘cancer-on-chip’ technology. While promising, problems with manufacturing to scale make them impractical for the moment.
The IMI-funded ITCCP4 project joined forces with US experts in paediatric cancer to reach a much-needed consensus on the best way forward for testing of childhood cancer drugs.
A roundup of some recent IMI cancer progress stories, and cancer-related projects launched in 2021
The IMI-funded ITCC-P4 project’s methodology helped identify some of the best targets in childhood tumours that could be candidates for treatment with adult therapies
The last Innovative Medicines Initiative (IMI) project to launch, FACILITATE will explore how we can return data from clinical trials to participants.
Researchers from COMBACTE-CDI filled important knowledge gaps on the scale of C. diff infections, and sequenced the genomes of hundreds of strains for future researchers
The European Liquid Biopsy Society, an offshoot of the IMI project CANCER-ID, is pushing the science on liquid biopsies closer to clinical reality
The HARMONY Alliance is using advanced data analysis methods based on artificial intelligence and machine learning to answer questions about haematological malignancies.
IMMUCAN researchers are using extensive imaging data and statistical analysis to produce detailed descriptions of tumours to figure out which regions should be investigated further...
The European Lead Factory has helped identify two drug candidates for cancer treatment that have now progressed to clinical testing.
HARMONY’s prototype may offer a more precise way for doctors to predict who should undergo the invasive and risky treatment.
Researchers from RADAR-CNS used deep learning to identity people with COVID19 from heart rate data fed by wearable physical fitness monitors.
EBOVAC2 received a special jury prize at the Étoiles de l'Europe awards for studies on the safety and immunogenicity of the Janssen vaccine in young, old, and HIV-infected people.
Scientists in PD-MitoQUANT are studying how breakdown in cells’ mitochondrial function is implicated in Parkinson’s disease. Tools developed by SME geneXplain are helping them do...
Research from the IMI projects ENABLE and ELF have discovered a treatment that could reverse antibiotic resistance in some bacteria.
Some people are at higher risk than others of dying after the common procedure. EHDEN’s modelling was able to identify them
Around half of all patient’s don’t take their treatment as prescribed. New Innovative Medicines Initiative (IMI) project BEAMER wants to find out why and develop guidance to...
DRIVE found fewer options for older people, and that younger people’s other risk factors play a part in the choice. This data is helping calculate the effectiveness of vaccination...
The new project focuses on respiratory syncytial virus (RSV), an infectious disease that can cause severe illness in young children and other vulnerable groups.
The new European Platform for Neurodegenerative Diseases (EPND) project will set up a collaborative platform that will link up existing sample and data infrastructures.
A large study, part-funded by the Innovative Medicines Initiative (IMI) through the DIRECT, SUMMIT and BEAT-DKD projects, identified a protein in the blood that could predict type...
The Innovative Medicines Initiative (IMI) organically grew into a powerhouse of international alliances. The new partnership’s multi-sectoral nature means that the catchment will...
PREFER’s proposals have been described by the EMA as a “comprehensive reference document for planning and conducting patient preference studies’’
EHDEN generates evidence for diseases and treatments using a network of nearly 100 data partners and over 400 million electronic health records
Studies of medicines safety and breastfeeding often involve animals. Now IMI’s CONCEPTION project has a plan that could deliver better results while also using fewer animals.
PRISM is in talks with the EMA on the use of data from smartphones and wearables as biomarkers of social functioning in neuropsychiatric disorders.
Most research into autoimmune diseases focuses on the role of the immune system. But INNODIA research underscores the importance of studying the tissues under attack as well
RESCEU have put together the most comprehensive cache of evidence to date on the true burden of a disease that still claims millions of mostly infant victims every year
Over 1 000 people have signed up to the EHDEN Academy, which provides the global scientific community with free educational resources on real world data and real world evidence.
AMYPAD researchers have shown that a ‘visual read’ of PET scans using radioactive diagnostic tracer flutemetamol can go beyond simple yes-or-no determination of the presence of the...
ITCC-P4 are creating a platform of hundreds of childhood cancer tumour models that can be used to test promising molecules
c4c aims to enable hospitals and clinical sites across Europe to become ‘trial ready’ for paediatric clinical trials. We asked the team about the proof of viability studies that...
Thanks to WEB-RADR, a smartphone app is being used internationally for reporting side effects of medicines
MELLODDY have shown that ‘federated learning’ can be used to pool datasets from multiple pharma companies without revealing any valuable secrets
Former IMI patient education project EUPATI is going global with the launch of a national platform in Japan, and the translation into Japanese of its toolbox. The move highlights...
The INNODIA project is launching four diabetes drug studies, designed according to their regulator-approved master protocol
Researchers from MOPEAD tested different ways to engage patients, including reaching out to suspected early Alzheimer’s sufferers by flagging internet searches like 'forgetfulness'...
IMI’s EHDEN project dramatically demonstrated the power of using clinical data in research by replicating, during a five-day ‘study-a-thon’, the results of a systematic review...
The PHAGO project has identified two genes that might have a significant impact on Alzheimers disease development and progression.
IMI’s IMIDIA project set out to study the function of a certain type of cells found in the pancreas which, when malfunctioning or weak, are thought to cause diabetes. We spoke to...
IMI's RHAPSODY project researchers have split type 2 diabetes into subgroups and are working on a tool to personalise treatment for the disease. Their aim is to help patients get...
New treatments must be tested in clinical trials to ensure they are safe and effective. IMI's EHR4CR project has enabled scientists to find suitable patients by searching millions...
Before SUMMIT started in 2009, ongoing research on diabetic complications in Europe was scattered amongst various countries. Fast forward six years, and Europe – by joining forces...